Isoprenyl phosphinylformates: new inhibitors of squalene synthetase

J Med Chem. 1991 Jun;34(6):1912-4. doi: 10.1021/jm00110a024.
No abstract available

MeSH terms

  • Animals
  • Anticholesteremic Agents
  • Farnesyl-Diphosphate Farnesyltransferase / antagonists & inhibitors*
  • In Vitro Techniques
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / enzymology
  • Organophosphorus Compounds / chemical synthesis
  • Organophosphorus Compounds / pharmacology*
  • Rats
  • Structure-Activity Relationship
  • Terpenes / chemical synthesis
  • Terpenes / pharmacology*

Substances

  • Anticholesteremic Agents
  • Organophosphorus Compounds
  • Terpenes
  • Farnesyl-Diphosphate Farnesyltransferase