Altered phospholipase C activity in renal medulla of DOCA-salt hypertensive rats

Jpn Circ J. 1991 May;55(5):509-15. doi: 10.1253/jcj.55.509.

Abstract

We investigated the alterations of phospholipase C activity in the kidney and arterial wall of deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Neither DOCA nor salt administration alone affected phospholipase C activity in the kidney and arterial wall. In contrast, when the rats were given both DOCA and salt and developed high blood pressure, the phospholipase C activity became greater in the outer and inner medulla (papilla) while the enzyme activity was reduced significantly in the renal cortex and arterial wall. Such an increase in phospholipase C activity was not observed in the kidney of a genetic rat for spontaneous hypertension. Moreover, the phospholipase A2 activity was also stimulated in the renal medulla of DOCA-salt hypertensive rats. Thus, these data indicate that DOCA-salt hypertension is associated with an increase in phospholipase C activity in the renal medulla, which seems primary to the development of DOCA-salt hypertension.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Desoxycorticosterone / adverse effects
  • Hypertension / chemically induced
  • Hypertension / enzymology*
  • Kidney Medulla / enzymology*
  • Phospholipases A / metabolism
  • Phospholipases A2
  • Rats
  • Rats, Inbred SHR
  • Rats, Inbred Strains
  • Rats, Inbred WKY
  • Sodium Chloride / adverse effects
  • Type C Phospholipases / metabolism*

Substances

  • Desoxycorticosterone
  • Sodium Chloride
  • Phospholipases A
  • Phospholipases A2
  • Type C Phospholipases