A role for SIRT1 in the hypoxic response

Scott F Leiser; Matt Kaeberlein

doi:10.1016/j.molcel.2010.06.015

A role for SIRT1 in the hypoxic response

Mol Cell. 2010 Jun 25;38(6):779-80. doi: 10.1016/j.molcel.2010.06.015.

Authors

Scott F Leiser¹, Matt Kaeberlein

Affiliation

¹ Department of Pathology, University of Washington, Seattle, WA 98195, USA.

PMID: 20620950
DOI: 10.1016/j.molcel.2010.06.015

Abstract

In this issue of Molecular Cell, Lim et al. (2010) show that SIRT1 deacetylates HIF-1alpha and regulates its ability to respond to hypoxia, revealing yet another important function of SIRT1 and suggesting a connection between HIF function in aging and sirtuin enzymes.

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