Platelet aggregation inhibitors from the seeds of Swietenia mahagoni: inhibition of in vitro and in vivo platelet-activating factor-induced effects of tetranortriterpenoids related to swietenine and swietenolide

Planta Med. 1991 Feb;57(1):56-8. doi: 10.1055/s-2006-960018.

Abstract

The ether extract from the seeds of Swietenia mahagoni Jacq. (Meliaceae) was found to inhibit platelet-activating factor (PAF)-induced platelet aggregation. Systematic separation of the extract afforded twenty eight tetranortriterpenoids related to swietenine and swietenolide. Among them, several new compounds, named swietemahonin A, D, E, and G and 3-O-acetylswietenolide and 6-O-acetylswietenolide, showed a strong inhibition against PAF-induced aggregation in vitro and in vivo assays.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Male
  • Mice
  • Mice, Inbred ICR
  • Plant Extracts / pharmacology*
  • Platelet Activating Factor / antagonists & inhibitors
  • Platelet Aggregation Inhibitors / isolation & purification*
  • Rabbits
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology*

Substances

  • Plant Extracts
  • Platelet Activating Factor
  • Platelet Aggregation Inhibitors
  • Triterpenes