Clinical utility of genotypic resistance tests for HIV-1-infected patients with low-level virological failure

J Clin Microbiol. 2010 Sep;48(9):3358-9. doi: 10.1128/JCM.01335-10. Epub 2010 Jul 14.

Abstract

The usefulness of genotypic resistance tests (GRT) among HIV-1 patients with low-level virological failure (LLVF) was evaluated. Up to 78% of samples with <1,000 copies/ml were sequenced successfully. For samples with 50 to 200 copies/ml, the success rate was as high as 69%. LLVF should not deter clinicians from requesting GRT.

MeSH terms

  • Anti-HIV Agents / therapeutic use*
  • Genotype
  • HIV Infections / drug therapy*
  • HIV Infections / virology*
  • HIV-1 / drug effects*
  • HIV-1 / genetics*
  • HIV-1 / isolation & purification
  • Humans
  • Microbial Sensitivity Tests / methods
  • Mutation, Missense*
  • RNA, Viral / genetics*
  • Sequence Analysis, DNA
  • Viral Load

Substances

  • Anti-HIV Agents
  • RNA, Viral