The apo riboswitch as a molecular hydra

Joseph E Wedekind

doi:10.1016/j.str.2010.06.003

The apo riboswitch as a molecular hydra

Structure. 2010 Jul 14;18(7):757-8. doi: 10.1016/j.str.2010.06.003.

Author

Joseph E Wedekind¹

Affiliation

¹ Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry and Center for RNA Biology, Rochester, NY 14642, USA. [email protected]

Abstract

Riboswitches "sense" metabolites but knowledge is sparse for structures without bound ligand. Stoddard et al. (2010) determined an apo riboswitch structure "closed" to metabolite binding. Further SAXS, biochemical, and computational analyses support ensemble behavior with interconverting open and closed conformations.

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