Inflammasome inhibition as a pathogenic stealth mechanism

Cell Host Microbe. 2010 Jul 22;8(1):7-11. doi: 10.1016/j.chom.2010.06.005.

Abstract

The activation of inflammasomes containing NBD-LRR (NLRs) or non-NLRs is critical for effective host defense against microbial pathogens. Recent discoveries have uncovered a plethora of pathogenic strategies to inhibit inflammasome-mediated processing of IL-1beta and IL-18. We review recent evidence for viral and bacterial manipulation of the inflammasome, ranging from perturbation of caspase-1 activation to targeting of specific inflammasome components.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Bacteria / immunology*
  • Bacteria / pathogenicity
  • Bacterial Infections / immunology*
  • Bacterial Infections / microbiology
  • Down-Regulation*
  • Host-Pathogen Interactions*
  • Humans
  • Virus Diseases / immunology*
  • Virus Diseases / virology
  • Viruses / immunology*
  • Viruses / pathogenicity