Tilting at nodal windmills: planar cell polarity positions cilia to tell left from right

Nicole Santos; Jeremy F Reiter

doi:10.1016/j.devcel.2010.07.001

Tilting at nodal windmills: planar cell polarity positions cilia to tell left from right

Dev Cell. 2010 Jul 20;19(1):5-6. doi: 10.1016/j.devcel.2010.07.001.

Authors

Nicole Santos¹, Jeremy F Reiter

Affiliation

¹ Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158-2324, USA.

Abstract

Nodal flow orients the left-right axis in some vertebrates, and is generated by clockwise-rotating cilia that are tilted posteriorly. In a recent paper, Song et al. add to mounting evidence that the planar cell polarity (PCP) pathway coordinates posterior positioning of cilia and subsequent determination of left-right asymmetry.

Abstract

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