Abstract
We analyzed a homogeneous sample of 671 patients underwent total thyroidectomy for various pathologies evaluating the final histological diagnosis and seeking the association between thyroiditis and cancer. As is known to the literature the incidence of association between autoimmune disease and cancer is not exceptional. In our experience, we have shown it in 39 cases (18.6%). We also considered the genetic background RET/PTC which is more prevalent in cases of papillary carcinoma in an inflammatory environment; could be stimulant the study of specific molecular markers to identify targets to inhibit the inflammatory status in thyroid cancer prevention.
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Carcinoma, Papillary / complications
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Carcinoma, Papillary / diagnosis
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Carcinoma, Papillary / genetics
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Carcinoma, Papillary / surgery*
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Female
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Genetic Predisposition to Disease
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Humans
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Incidence
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Male
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Middle Aged
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Oncogene Proteins / genetics
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Oncogene Proteins, Fusion / genetics
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Protein-Tyrosine Kinases / genetics
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Proto-Oncogene Proteins c-ret / genetics
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Retrospective Studies
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Thyroid Neoplasms / complications
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Thyroid Neoplasms / diagnosis
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Thyroid Neoplasms / genetics
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Thyroid Neoplasms / surgery*
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Thyroidectomy*
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Thyroiditis / complications
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Thyroiditis / diagnosis
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Thyroiditis / genetics
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Thyroiditis / surgery*
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Treatment Outcome
Substances
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Oncogene Proteins
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Oncogene Proteins, Fusion
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Protein-Tyrosine Kinases
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Proto-Oncogene Proteins c-ret