Evaluation of nonenhancing tumor fraction assessed by dynamic contrast-enhanced MRI subtraction as a predictor of decrease in tumor volume in response to chemoradiotherapy in advanced cervical cancer

AJR Am J Roentgenol. 2010 Aug;195(2):524-7. doi: 10.2214/AJR.09.3437.

Abstract

Objective: In this study, we evaluated the feasibility of using dynamic contrast-enhanced MRI (DCE-MRI) subtracted images as a predictor of a decrease in tumor volume in response to chemoradiotherapy in 13 patients with cervical cancer.

Conclusion: This study shows that pretreatment tumor nonenhancing fraction assessed with arterial image subtraction inversely predicts the chemoradiation response in cervical cancer.

MeSH terms

  • Adult
  • Chemotherapy, Adjuvant*
  • Contrast Media
  • Female
  • Gadolinium DTPA*
  • Humans
  • Image Enhancement / methods*
  • Magnetic Resonance Imaging / methods*
  • Middle Aged
  • Prognosis
  • Radiotherapy, Adjuvant*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Subtraction Technique*
  • Treatment Outcome
  • Uterine Cervical Neoplasms / diagnosis*
  • Uterine Cervical Neoplasms / therapy*
  • Young Adult

Substances

  • Contrast Media
  • Gadolinium DTPA