Abstract
A one-pot route to 8-substituted xanthines has been developed from 5,6-diaminouracils and carboxaldehydes. Yields are good and the process applicable to a range of substrates including a family of A(2A) adenosine receptor antagonists. A new route to the KW-6002 family of antagonists is presented including a pro-drug variant, and application to related image contrast agents developed.
MeSH terms
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Adenosine A2 Receptor Antagonists / chemical synthesis*
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Adenosine A2 Receptor Antagonists / chemistry
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Molecular Structure
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Prodrugs / chemical synthesis*
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Prodrugs / chemistry
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Purines / chemical synthesis*
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Purines / chemistry
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Receptor, Adenosine A2A / metabolism
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Stereoisomerism
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Xanthine / chemical synthesis*
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Xanthine / chemistry
Substances
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Adenosine A2 Receptor Antagonists
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Prodrugs
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Purines
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Receptor, Adenosine A2A
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Xanthine
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istradefylline