Endometrial expression of relaxin and relaxin receptor in endometriosis

Fertil Steril. 2010 Dec;94(7):2885-7. doi: 10.1016/j.fertnstert.2010.06.051. Epub 2010 Jul 23.

Abstract

Our studies demonstrate significantly lower expression of relaxin and its receptor in ectopic endometriotic tissues than their expression in eutopic endometrium and in endometrium from normal controls. These data suggest that in normal and eutopic endometrium, relaxin may exert a protective effect against endometriosis.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Case-Control Studies
  • Endometriosis / genetics*
  • Endometriosis / metabolism
  • Endometriosis / pathology
  • Endometrium / metabolism*
  • Endometrium / pathology
  • Female
  • Gene Expression / physiology
  • Humans
  • Menstrual Cycle / genetics
  • Menstrual Cycle / metabolism
  • Menstrual Cycle / physiology
  • Ovarian Diseases / genetics*
  • Ovarian Diseases / metabolism
  • Ovarian Diseases / pathology
  • Receptors, G-Protein-Coupled / genetics*
  • Receptors, G-Protein-Coupled / metabolism
  • Receptors, G-Protein-Coupled / physiology
  • Receptors, Peptide / genetics*
  • Receptors, Peptide / metabolism
  • Receptors, Peptide / physiology
  • Relaxin / genetics*
  • Relaxin / metabolism
  • Relaxin / physiology
  • Young Adult

Substances

  • RXFP1 protein, human
  • Receptors, G-Protein-Coupled
  • Receptors, Peptide
  • Relaxin