Equine acquired multiple acyl-CoA dehydrogenase deficiency (MADD) in 14 horses associated with ingestion of Maple leaves (Acer pseudoplatanus) covered with European tar spot (Rhytisma acerinum)

J H van der Kolk; I D Wijnberg; C M Westermann; L Dorland; M G M de Sain-van der Velden; L C Kranenburg; M Duran; J A Dijkstra; J J van der Lugt; R J A Wanders; E Gruys

doi:10.1016/j.ymgme.2010.06.019

Equine acquired multiple acyl-CoA dehydrogenase deficiency (MADD) in 14 horses associated with ingestion of Maple leaves (Acer pseudoplatanus) covered with European tar spot (Rhytisma acerinum)

Mol Genet Metab. 2010 Oct-Nov;101(2-3):289-91. doi: 10.1016/j.ymgme.2010.06.019. Epub 2010 Jul 23.

Authors

J H van der Kolk¹, I D Wijnberg, C M Westermann, L Dorland, M G M de Sain-van der Velden, L C Kranenburg, M Duran, J A Dijkstra, J J van der Lugt, R J A Wanders, E Gruys

Affiliation

¹ Department of Equine Sciences, Medicine Section, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands. [email protected]

PMID: 20655779
DOI: 10.1016/j.ymgme.2010.06.019

Abstract

This case-series describes fourteen horses suspected of equine acquired multiple acyl-CoA dehydrogenase deficiency (MADD) also known as atypical myopathy of which seven cases were confirmed biochemically with all horses having had access to leaves of the Maple tree (Acer pseudoplatanus) covered with European tar spot (Rhytisma acerinum). Assessment of organic acids, glycine conjugates, and acylcarnitines in urine was regarded as gold standard in the biochemical diagnosis of equine acquired multiple acyl-CoA dehydrogenase deficiency.

MeSH terms

Acer*
Animals
Ascomycota
Carboxylic Acids / urine
Carnitine / analogs & derivatives
Carnitine / urine
Female
Foodborne Diseases / veterinary*
Glycine / urine
Horse Diseases / enzymology*
Horse Diseases / urine
Horses
Male
Multiple Acyl Coenzyme A Dehydrogenase Deficiency / veterinary*
Plant Diseases / microbiology
Plant Leaves*

Substances

Carboxylic Acids
acylcarnitine
Carnitine
Glycine