The total branch length of sample genealogies in populations of variable size

Genetics. 2010 Oct;186(2):601-11. doi: 10.1534/genetics.110.117135. Epub 2010 Jul 26.

Abstract

We consider neutral evolution of a large population subject to changes in its population size. For a population with a time-variable carrying capacity we study the distribution of the total branch lengths of its sample genealogies. Within the coalescent approximation we have obtained a general expression-Equation 20-for the moments of this distribution with a given arbitrary dependence of the population size on time. We investigate how the frequency of population-size variations alters the total branch length.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Data Interpretation, Statistical
  • Demography
  • Genetic Drift
  • Genetic Variation*
  • Humans
  • Models, Genetic*
  • Pedigree
  • Population Density*
  • Population Dynamics