Structure of single-wall peptide nanotubes: in situ flow aligning X-ray diffraction

Chem Commun (Camb). 2010 Sep 14;46(34):6270-2. doi: 10.1039/c0cc00212g. Epub 2010 Jul 29.

Abstract

The structure of single wall peptide nanotubes is presented for the model surfactant-like peptide A(6)K. Capillary flow alignment of a sample in the nematic phase at high concentration in water leads to oriented X-ray diffraction patterns. Analysis of these, accompanied by molecular dynamics simulations, suggests the favourable self-assembly of antiparallel peptide dimers into beta-sheet ribbons that wrap helically to form the nanotube wall.

MeSH terms

  • Crystallography, X-Ray
  • Models, Molecular
  • Molecular Dynamics Simulation
  • Nanotubes, Peptide / chemistry*
  • Oligopeptides / chemistry*
  • Protein Conformation

Substances

  • Nanotubes, Peptide
  • Oligopeptides
  • acetyl-alanyl-alanyl-alanyl-alanyl-alanyl-alanyl-lysine