Improved Arndt-Eistert synthesis of alpha-diazoketones requiring minimal diazomethane in the presence of calcium oxide as acid scavenger

J Org Chem. 2010 Aug 20;75(16):5760-3. doi: 10.1021/jo101105g.

Abstract

A practical methodology to obtain alpha-diazoketones through an improved Arndt-Eistert synthesis is described. The method allows the efficient transformation of acid halides using a stoichiometric amount of diazomethane in the presence of calcium oxide, without concomitant ketene or haloketone formation. The obtained alpha'-brominated-alpha-diazoketones were employed as suitable substrates for the synthesis of interesting alpha-arylamino-alpha'-halomethylketones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Calcium Compounds / chemistry*
  • Diazomethane / chemistry*
  • Ketones / chemical synthesis*
  • Ketones / chemistry
  • Molecular Structure
  • Oxides / chemistry*
  • Stereoisomerism

Substances

  • Calcium Compounds
  • Ketones
  • Oxides
  • Diazomethane
  • lime