Characterization of H5N1 highly pathogenic avian influenza virus strains isolated from migratory waterfowl in Mongolia on the way back from the southern Asia to their northern territory

Virology. 2010 Oct 10;406(1):88-94. doi: 10.1016/j.virol.2010.07.007. Epub 2010 Jul 31.

Abstract

H5N1 highly pathogenic avian influenza (HPAI) viruses were isolated from dead wild waterfowl at Khunt, Erkhel, Doityn Tsagaan, Doroo, and Ganga Lakes in Mongolia in July 2005, May 2006, May 2009, July 2009, and May 2010, respectively. The isolates in 2005 and 2006 were classified into genetic clade 2.2, and those in 2009 and 2010 into clade 2.3.2. A/whooper swan/Mongolia/6/2009 (H5N1) experimentally infected ducks and replicated systemically with higher mortality than that of the isolates in 2005 and 2006. Intensive surveillance of avian influenza in migratory waterfowl flying from their nesting lakes in Siberia to Mongolia in every autumn indicate that HPAI viruses have not perpetuated at their nesting lakes until 2009. The present results demonstrate that wild waterfowl were sporadically infected with H5N1 HPAI viruses prevailing in domestic poultry in the southern Asia and died in Mongolia on the way back to their northern territory in spring.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animal Migration
  • Animals
  • Anseriformes / virology*
  • Asia
  • Chickens
  • Ducks
  • Hemagglutinin Glycoproteins, Influenza Virus / genetics
  • Influenza A Virus, H5N1 Subtype / classification
  • Influenza A Virus, H5N1 Subtype / genetics
  • Influenza A Virus, H5N1 Subtype / isolation & purification*
  • Influenza A Virus, H5N1 Subtype / pathogenicity
  • Influenza in Birds / transmission
  • Influenza in Birds / virology*
  • Molecular Sequence Data
  • Mongolia
  • Phylogeny
  • Poultry / virology
  • Species Specificity
  • Sus scrofa
  • Swine
  • Virulence

Substances

  • Hemagglutinin Glycoproteins, Influenza Virus

Associated data

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