The genome sequence of the cyanobacterium Oscillatoria sp. PCC 6506 reveals several gene clusters responsible for the biosynthesis of toxins and secondary metabolites

Annick Méjean; Rabia Mazmouz; Stéphane Mann; Alexandra Calteau; Claudine Médigue; Olivier Ploux

doi:10.1128/JB.00704-10

The genome sequence of the cyanobacterium Oscillatoria sp. PCC 6506 reveals several gene clusters responsible for the biosynthesis of toxins and secondary metabolites

J Bacteriol. 2010 Oct;192(19):5264-5. doi: 10.1128/JB.00704-10. Epub 2010 Jul 30.

Authors

Annick Méjean¹, Rabia Mazmouz, Stéphane Mann, Alexandra Calteau, Claudine Médigue, Olivier Ploux

Affiliation

¹ Laboratoire Charles Friedel, UMR CNRS 7223, ENSCP Chimie ParisTech, 11 Rue Pierre et Marie Curie, 75231 Paris Cedex 05, France. [email protected]

Abstract

We report a draft sequence of the genome of Oscillatoria sp. PCC 6506, a cyanobacterium that produces anatoxin-a and homoanatoxin-a, two neurotoxins, and cylindrospermopsin, a cytotoxin. Beside the clusters of genes responsible for the biosynthesis of these toxins, we have found other clusters of genes likely involved in the biosynthesis of not-yet-identified secondary metabolites.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacterial Toxins / genetics
Genome, Bacterial / genetics*
Molecular Sequence Data
Multigene Family / genetics*
Multigene Family / physiology
Oscillatoria / genetics*

Substances

Bacterial Toxins

Associated data

GENBANK/CACA01000001
GENBANK/CACA01000002
GENBANK/CACA01000003
GENBANK/CACA01000004
GENBANK/CACA01000005
GENBANK/CACA01000006
GENBANK/CACA01000007
GENBANK/CACA01000008
GENBANK/CACA01000009
GENBANK/CACA01000010
GENBANK/CACA01000011
GENBANK/CACA01000012
GENBANK/CACA01000013
GENBANK/CACA01000014
GENBANK/CACA01000015
GENBANK/CACA01000016
GENBANK/CACA01000017
GENBANK/CACA01000018
GENBANK/CACA01000019
GENBANK/CACA01000020
GENBANK/CACA01000021
GENBANK/CACA01000022
GENBANK/CACA01000023
GENBANK/CACA01000024
GENBANK/CACA01000025
GENBANK/CACA01000026
GENBANK/CACA01000027
GENBANK/CACA01000028
GENBANK/CACA01000029
GENBANK/CACA01000030
GENBANK/CACA01000031
GENBANK/CACA01000032
GENBANK/CACA01000033
GENBANK/CACA01000034
GENBANK/CACA01000035
GENBANK/CACA01000036
GENBANK/CACA01000037
GENBANK/CACA01000038
GENBANK/CACA01000039
GENBANK/CACA01000040
GENBANK/CACA01000041
GENBANK/CACA01000042
GENBANK/CACA01000043
GENBANK/CACA01000044
GENBANK/CACA01000045
GENBANK/CACA01000046
GENBANK/CACA01000047
GENBANK/CACA01000048
GENBANK/CACA01000049
GENBANK/CACA01000050
GENBANK/CACA01000051
GENBANK/CACA01000052
GENBANK/CACA01000053
GENBANK/CACA01000054
GENBANK/CACA01000055
GENBANK/CACA01000056
GENBANK/CACA01000057
GENBANK/CACA01000058
GENBANK/CACA01000059
GENBANK/CACA01000060
GENBANK/CACA01000061
GENBANK/CACA01000062
GENBANK/CACA01000063
GENBANK/CACA01000064
GENBANK/CACA01000065
GENBANK/CACA01000066
GENBANK/CACA01000067
GENBANK/CACA01000068
GENBANK/CACA01000069
GENBANK/CACA01000070
GENBANK/CACA01000071
GENBANK/CACA01000072
GENBANK/CACA01000073
GENBANK/CACA01000074
GENBANK/CACA01000075
GENBANK/CACA01000076
GENBANK/CACA01000077
GENBANK/CACA01000078
GENBANK/CACA01000079
GENBANK/CACA01000080
GENBANK/CACA01000081
GENBANK/CACA01000082
GENBANK/CACA01000083
GENBANK/CACA01000084
GENBANK/CACA01000085
GENBANK/CACA01000086
GENBANK/CACA01000087
GENBANK/CACA01000088
GENBANK/CACA01000089
GENBANK/CACA01000090
GENBANK/CACA01000091
GENBANK/CACA01000092
GENBANK/CACA01000093
GENBANK/CACA01000094
GENBANK/CACA01000095
GENBANK/CACA01000096
GENBANK/CACA01000097
GENBANK/CACA01000098
GENBANK/CACA01000099
GENBANK/CACA01000100
GENBANK/CACA01000101
GENBANK/CACA01000102
GENBANK/CACA01000103
GENBANK/CACA01000104
GENBANK/CACA01000105
GENBANK/CACA01000106
GENBANK/CACA01000107
GENBANK/CACA01000108
GENBANK/CACA01000109
GENBANK/CACA01000110
GENBANK/CACA01000111
GENBANK/CACA01000112
GENBANK/CACA01000113
GENBANK/CACA01000114
GENBANK/CACA01000115
GENBANK/CACA01000116
GENBANK/CACA01000117
GENBANK/CACA01000118
GENBANK/CACA01000119
GENBANK/CACA01000120
GENBANK/CACA01000121
GENBANK/CACA01000122
GENBANK/CACA01000123
GENBANK/CACA01000124
GENBANK/CACA01000125
GENBANK/CACA01000126
GENBANK/CACA01000127
GENBANK/CACA01000128
GENBANK/CACA01000129
GENBANK/CACA01000130
GENBANK/CACA01000131
GENBANK/CACA01000132
GENBANK/CACA01000133
GENBANK/CACA01000134
GENBANK/CACA01000135
GENBANK/CACA01000136
GENBANK/CACA01000137
GENBANK/CACA01000138
GENBANK/CACA01000139
GENBANK/CACA01000140
GENBANK/CACA01000141
GENBANK/CACA01000142
GENBANK/CACA01000143
GENBANK/CACA01000144
GENBANK/CACA01000145
GENBANK/CACA01000146
GENBANK/CACA01000147
GENBANK/CACA01000148
GENBANK/CACA01000149
GENBANK/CACA01000150
GENBANK/CACA01000151
GENBANK/CACA01000152
GENBANK/CACA01000153
GENBANK/CACA01000154
GENBANK/CACA01000155
GENBANK/CACA01000156
GENBANK/CACA01000157
GENBANK/CACA01000158
GENBANK/CACA01000159
GENBANK/CACA01000160
GENBANK/CACA01000161
GENBANK/CACA01000162
GENBANK/CACA01000163
GENBANK/CACA01000164
GENBANK/CACA01000165
GENBANK/CACA01000166
GENBANK/CACA01000167
GENBANK/CACA01000168
GENBANK/CACA01000169
GENBANK/CACA01000170
GENBANK/CACA01000171
GENBANK/CACA01000172
GENBANK/CACA01000173
GENBANK/CACA01000174
GENBANK/CACA01000175
GENBANK/CACA01000176
GENBANK/CACA01000177
GENBANK/CACA01000178
GENBANK/CACA01000179
GENBANK/CACA01000180
GENBANK/CACA01000181
GENBANK/CACA01000182
GENBANK/CACA01000183
GENBANK/CACA01000184
GENBANK/CACA01000185
GENBANK/CACA01000186
GENBANK/CACA01000187
GENBANK/CACA01000188
GENBANK/CACA01000189
GENBANK/CACA01000190
GENBANK/CACA01000191
GENBANK/CACA01000192
GENBANK/CACA01000193
GENBANK/CACA01000194
GENBANK/CACA01000195
GENBANK/CACA01000196
GENBANK/CACA01000197
GENBANK/CACA01000198
GENBANK/CACA01000199
GENBANK/CACA01000200
GENBANK/CACA01000201
GENBANK/CACA01000202
GENBANK/CACA01000203
GENBANK/CACA01000204
GENBANK/CACA01000205
GENBANK/CACA01000206
GENBANK/CACA01000207
GENBANK/CACA01000208
GENBANK/CACA01000209
GENBANK/CACA01000210
GENBANK/CACA01000211
GENBANK/CACA01000212
GENBANK/CACA01000213
GENBANK/CACA01000214
GENBANK/CACA01000215
GENBANK/CACA01000216
GENBANK/CACA01000217
GENBANK/CACA01000218
GENBANK/CACA01000219
GENBANK/CACA01000220
GENBANK/CACA01000221
GENBANK/CACA01000222
GENBANK/CACA01000223
GENBANK/CACA01000224
GENBANK/CACA01000225
GENBANK/CACA01000226
GENBANK/CACA01000227
GENBANK/CACA01000228
GENBANK/CACA01000229
GENBANK/CACA01000230
GENBANK/CACA01000231
GENBANK/CACA01000232
GENBANK/CACA01000233
GENBANK/CACA01000234
GENBANK/CACA01000235
GENBANK/CACA01000236
GENBANK/CACA01000237
GENBANK/CACA01000238
GENBANK/CACA01000239
GENBANK/CACA01000240
GENBANK/CACA01000241
GENBANK/CACA01000242
GENBANK/CACA01000243
GENBANK/CACA01000244
GENBANK/CACA01000245
GENBANK/CACA01000246
GENBANK/CACA01000247
GENBANK/CACA01000248
GENBANK/CACA01000249
GENBANK/CACA01000250
GENBANK/CACA01000251
GENBANK/CACA01000252
GENBANK/CACA01000253
GENBANK/CACA01000254
GENBANK/CACA01000255
GENBANK/CACA01000256
GENBANK/CACA01000257
GENBANK/CACA01000258
GENBANK/CACA01000259
GENBANK/CACA01000260
GENBANK/CACA01000261
GENBANK/CACA01000262
GENBANK/CACA01000263
GENBANK/CACA01000264
GENBANK/CACA01000265
GENBANK/CACA01000266
GENBANK/CACA01000267
GENBANK/CACA01000268
GENBANK/CACA01000269
GENBANK/CACA01000270
GENBANK/CACA01000271
GENBANK/CACA01000272
GENBANK/CACA01000273
GENBANK/CACA01000274
GENBANK/CACA01000275
GENBANK/CACA01000276
GENBANK/CACA01000277
GENBANK/CACA01000278
GENBANK/CACA01000279
GENBANK/CACA01000280
GENBANK/CACA01000281
GENBANK/CACA01000282
GENBANK/CACA01000283
GENBANK/CACA01000284
GENBANK/CACA01000285
GENBANK/CACA01000286
GENBANK/CACA01000287
GENBANK/CACA01000288
GENBANK/CACA01000289
GENBANK/CACA01000290
GENBANK/CACA01000291
GENBANK/CACA01000292
GENBANK/CACA01000293
GENBANK/CACA01000294
GENBANK/CACA01000295
GENBANK/CACA01000296
GENBANK/CACA01000297
GENBANK/CACA01000298
GENBANK/CACA01000299
GENBANK/CACA01000300
GENBANK/CACA01000301
GENBANK/CACA01000302
GENBANK/CACA01000303
GENBANK/CACA01000304
GENBANK/CACA01000305
GENBANK/CACA01000306
GENBANK/CACA01000307
GENBANK/CACA01000308
GENBANK/CACA01000309
GENBANK/CACA01000310
GENBANK/CACA01000311
GENBANK/CACA01000312
GENBANK/CACA01000313
GENBANK/CACA01000314
GENBANK/CACA01000315
GENBANK/CACA01000316
GENBANK/CACA01000317
GENBANK/CACA01000318
GENBANK/CACA01000319
GENBANK/CACA01000320
GENBANK/CACA01000321
GENBANK/CACA01000322
GENBANK/CACA01000323
GENBANK/CACA01000324
GENBANK/CACA01000325
GENBANK/CACA01000326
GENBANK/CACA01000327
GENBANK/CACA01000328
GENBANK/CACA01000329
GENBANK/CACA01000330
GENBANK/CACA01000331
GENBANK/CACA01000332
GENBANK/CACA01000333
GENBANK/CACA01000334
GENBANK/CACA01000335
GENBANK/CACA01000336
GENBANK/CACA01000337
GENBANK/CACA01000338
GENBANK/CACA01000339
GENBANK/CACA01000340
GENBANK/CACA01000341
GENBANK/CACA01000342
GENBANK/CACA01000343
GENBANK/CACA01000344
GENBANK/CACA01000345
GENBANK/CACA01000346
GENBANK/CACA01000347
GENBANK/CACA01000348
GENBANK/CACA01000349
GENBANK/CACA01000350
GENBANK/CACA01000351
GENBANK/CACA01000352
GENBANK/CACA01000353
GENBANK/CACA01000354
GENBANK/CACA01000355
GENBANK/CACA01000356
GENBANK/CACA01000357
GENBANK/CACA01000358
GENBANK/CACA01000359
GENBANK/CACA01000360
GENBANK/CACA01000361
GENBANK/CACA01000362
GENBANK/CACA01000363
GENBANK/CACA01000364
GENBANK/CACA01000365
GENBANK/CACA01000366
GENBANK/CACA01000367
GENBANK/CACA01000368
GENBANK/CACA01000369
GENBANK/CACA01000370
GENBANK/CACA01000371
GENBANK/CACA01000372
GENBANK/CACA01000373
GENBANK/CACA01000374
GENBANK/CACA01000375
GENBANK/CACA01000376
GENBANK/CACA01000377