Graft-induced dyskinesias in Parkinson's disease: what is it all about?

Roger A Barker; Wei-Li Kuan

doi:10.1016/j.stem.2010.07.003

Graft-induced dyskinesias in Parkinson's disease: what is it all about?

Cell Stem Cell. 2010 Aug 6;7(2):148-9. doi: 10.1016/j.stem.2010.07.003.

Authors

Roger A Barker¹, Wei-Li Kuan

Affiliation

¹ Brain Repair Centre and Department of Neurology, University of Cambridge, Cambridge CB2 0PY, UK. [email protected]

PMID: 20682443
DOI: 10.1016/j.stem.2010.07.003

Abstract

The treatment of Parkinson's disease with grafts of fetal ventral mesencephalic tissue has shown some success, but can result in graft-induced dyskinesias (GIDs). Recently in Science Translational Medicine, Politis et al. (2010) demonstrate that GIDs may originate from serotoninergic neurons that are cografted in these transplants.

MeSH terms

Animals
Brain Tissue Transplantation / adverse effects*
Buspirone / therapeutic use
Dyskinesias / drug therapy
Dyskinesias / etiology*
Fetal Tissue Transplantation / adverse effects*
Humans
Neurons / metabolism
Parkinson Disease / complications*
Parkinson Disease / surgery*
Serotonin / metabolism
Stem Cell Transplantation

Substances

Serotonin
Buspirone