False-positive rate of a "fourth-generation" HIV antigen/antibody combination assay in an area of low HIV prevalence

Clin Vaccine Immunol. 2010 Oct;17(10):1642-4. doi: 10.1128/CVI.00258-10. Epub 2010 Aug 4.

Abstract

We retrospectively analyzed the performance of the Architect HIV antigen/antibody (Ag/Ab) combination assay in a tertiary health care center with a situation of low HIV prevalence. The specificity and positive predictive value (PPV) were 99.78% and 31.21%, respectively. However, the specificity and PPV could increase to 99.99% and 89.70% using an arbitrary cutoff value.

Publication types

  • Evaluation Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, Viral / blood*
  • Child
  • Child, Preschool
  • False Positive Reactions*
  • Female
  • HIV Antibodies / blood*
  • HIV Infections / diagnosis*
  • HIV Infections / epidemiology
  • Humans
  • Immunoassay / methods
  • Infant
  • Infant, Newborn
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Prevalence
  • Retrospective Studies
  • Sensitivity and Specificity
  • Virology / methods*
  • Young Adult

Substances

  • Antigens, Viral
  • HIV Antibodies