AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3

Leukemia. 2010 Oct;24(10):1785-8. doi: 10.1038/leu.2010.158. Epub 2010 Aug 5.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Blotting, Western
  • Cell Proliferation / drug effects
  • Female
  • Flow Cytometry
  • Granulocyte-Macrophage Colony-Stimulating Factor / metabolism*
  • Humans
  • Interleukin Receptor Common gamma Subunit / physiology*
  • Interleukin-3 / metabolism*
  • Leukemia, Myeloid, Acute / genetics
  • Leukemia, Myeloid, Acute / metabolism*
  • Leukemia, Myeloid, Acute / pathology
  • Male
  • Mice
  • Mice, Inbred NOD
  • Mice, Knockout
  • Mice, SCID
  • RNA, Messenger / genetics
  • Reverse Transcriptase Polymerase Chain Reaction
  • Stem Cell Factor / metabolism*
  • Xenograft Model Antitumor Assays*

Substances

  • Il2rg protein, mouse
  • Interleukin Receptor Common gamma Subunit
  • Interleukin-3
  • RNA, Messenger
  • Stem Cell Factor
  • Granulocyte-Macrophage Colony-Stimulating Factor