Abstract
New oxathiazinane dioxides have been derived from D- and L-serine and tested for their in vitro cell growth inhibitory activity toward SKBR3 breast cancer cells. (5R)-5-(4-(4'-Bromomethyl)phenyl)benzyloxymethyl-[1,3,4]-oxathiazinane-3,3-dioxide showed a cytotoxicity of IC(50) approximately 10 microM.
Copyright 2009 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Breast Neoplasms / pathology*
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Cell Division / drug effects*
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Female
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Humans
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In Vitro Techniques
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Inhibitory Concentration 50
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Thiazines / chemical synthesis*
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Thiazines / pharmacology*
Substances
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Antineoplastic Agents
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Thiazines