Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity

Bioorg Med Chem Lett. 2010 Sep 1;20(17):5353-6. doi: 10.1016/j.bmcl.2009.09.019. Epub 2009 Sep 10.

Abstract

New oxathiazinane dioxides have been derived from D- and L-serine and tested for their in vitro cell growth inhibitory activity toward SKBR3 breast cancer cells. (5R)-5-(4-(4'-Bromomethyl)phenyl)benzyloxymethyl-[1,3,4]-oxathiazinane-3,3-dioxide showed a cytotoxicity of IC(50) approximately 10 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology*
  • Breast Neoplasms / pathology*
  • Cell Division / drug effects*
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Female
  • Humans
  • In Vitro Techniques
  • Inhibitory Concentration 50
  • Thiazines / chemical synthesis*
  • Thiazines / pharmacology*

Substances

  • Antineoplastic Agents
  • Thiazines