Successful treatment of pan-resistant Klebsiella pneumoniae pneumonia and bacteraemia with a combination of high-dose tigecycline and colistin

J Med Microbiol. 2010 Nov;59(Pt 11):1383-1386. doi: 10.1099/jmm.0.023010-0. Epub 2010 Aug 5.

Abstract

The spread of antimicrobial resistance among members of the Enterobacteriaceae is a significant clinical threat. We report the treatment of pan-resistant Klebsiella pneumoniae bacteraemia with combination tigecycline and colistin in a 49-year-old male and review available therapeutic options. Despite a poor prognosis, the patient recovered, but remains colonized with the pan-resistant isolate.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Anti-Bacterial Agents / administration & dosage*
  • Anti-Bacterial Agents / pharmacology
  • Bacteremia / complications*
  • Bacteremia / diagnosis
  • Bacteremia / drug therapy
  • Colistin / administration & dosage*
  • Drug Resistance, Multiple, Bacterial
  • Drug Therapy, Combination / methods
  • Humans
  • Klebsiella Infections / complications*
  • Klebsiella Infections / diagnosis
  • Klebsiella Infections / drug therapy
  • Klebsiella pneumoniae / isolation & purification*
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Minocycline / administration & dosage
  • Minocycline / analogs & derivatives*
  • Pneumonia, Bacterial / complications*
  • Pneumonia, Bacterial / diagnosis
  • Pneumonia, Bacterial / drug therapy
  • Tigecycline

Substances

  • Anti-Bacterial Agents
  • Tigecycline
  • Minocycline
  • Colistin