Abstract
Palhinine A, a novel C(16)N-type Lycopodium alkaloid with a unique 5/6/6/9 tetracyclic ring system, was isolated from the whole plant of Palhinhaea cernua L. (Lycopodiaceae). Its structure was elucidated by spectroscopic methods, and the absolute configuration was determined by single-crystal X-ray diffraction analysis using the Flack parameter. Palhinine A is reported as the first example of Lycopodium alkaloids of which C-16 is fused to a new ring through a C-16-C-4 lingkage.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholinesterase / drug effects
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Alkaloids / chemistry*
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Crystallography, X-Ray
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Drug Screening Assays, Antitumor
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Humans
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K562 Cells
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Lycopodium / chemistry*
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
Substances
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Alkaloids
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Antineoplastic Agents, Phytogenic
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palhinine A
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Acetylcholinesterase