Anti-NMDA-receptor encephalitis in a 3 year old patient with chromosome 6p21.32 microdeletion including the HLA cluster

Eur J Paediatr Neurol. 2011 Mar;15(2):163-6. doi: 10.1016/j.ejpn.2010.07.004. Epub 2010 Aug 6.

Abstract

Anti-NMDA-receptor encephalitis was initially described as a paraneoplastic disorder in young women with ovarian teratoma. We report on a 3-year-old boy who developed anti-NMDA-receptor encephalitis one month after a respiratory infection. Moreover, array-comparative genomic hybridization in this patient revealed an inherited microdeletion in chromosomeband 6p21.32, including the HLA-DPB1 and HLA-DPB2 genes. The clinical relevance of this microdeletion is discussed.

Publication types

  • Case Reports

MeSH terms

  • Autoantibodies / biosynthesis*
  • Child, Preschool
  • Chromosomes, Human, Pair 6 / genetics*
  • Encephalitis / genetics*
  • Encephalitis / immunology*
  • Encephalitis / metabolism
  • Gene Deletion*
  • Genetic Predisposition to Disease / genetics*
  • HLA-D Antigens / genetics*
  • Humans
  • Male
  • Receptors, N-Methyl-D-Aspartate / immunology*

Substances

  • Autoantibodies
  • HLA-D Antigens
  • Receptors, N-Methyl-D-Aspartate