Dendrite plasticity in the lateral geniculate nucleus in primate glaucoma

Vision Res. 2011 Jan 28;51(2):243-50. doi: 10.1016/j.visres.2010.08.003. Epub 2010 Aug 6.

Abstract

Neural degeneration in glaucoma involves retinal ganglion cells and neurons of their major target, the lateral geniculate nucleus (LGN). Dendrites of relay LGN neurons projecting to the visual cortex were studied by immunocytochemical and quantitative Sholl analysis in combination with confocal microscopy and 3D-morphometry. In non-human adult primate glaucoma, relay LGN neurons showed reduced dendrite complexity and length, and these changes were modified by NMDA receptor blockade. Dendrite plasticity of LGN relay neurons in adult primate glaucoma has implications for potential disease modification by treatment interventions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dendrites / pathology*
  • Disease Models, Animal
  • Geniculate Bodies / metabolism
  • Geniculate Bodies / pathology*
  • Glaucoma / pathology*
  • Immunohistochemistry
  • Macaca fascicularis / physiology
  • Microtubule-Associated Proteins / metabolism
  • Neurons / pathology

Substances

  • Microtubule-Associated Proteins