Abstract
We report a case of suggestive synchronous triple squamous cell carcinoma (Sq) of the lung that occurred in the same lobe. Under a clinical diagnosis of triple lung cancer, lobectomy was performed. Pathological examination revealed two well-differentiated Sq and one poorly differentiated Sq. The analysis of epidermal growth factor receptor-tyrosine kinase mutations showed no mutation in each tumor. However, pathological findings and the positive rate of immunochemical reaction of p53 and Ki-67 were different in each tumor.
MeSH terms
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Aged
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Carcinoma, Squamous Cell / chemistry
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Carcinoma, Squamous Cell / genetics
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Carcinoma, Squamous Cell / pathology*
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Carcinoma, Squamous Cell / surgery
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Cell Differentiation
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ErbB Receptors / genetics
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Female
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Humans
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Ki-67 Antigen / analysis
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Lung Neoplasms / chemistry
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Lung Neoplasms / genetics
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Lung Neoplasms / pathology*
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Lung Neoplasms / surgery
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Mutation
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Neoplasm Staging
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Neoplasms, Multiple Primary / chemistry
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Neoplasms, Multiple Primary / genetics
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Neoplasms, Multiple Primary / pathology*
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Neoplasms, Multiple Primary / surgery
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Pneumonectomy
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Tomography, X-Ray Computed
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Treatment Outcome
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Tumor Suppressor Protein p53 / analysis
Substances
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Ki-67 Antigen
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TP53 protein, human
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Tumor Suppressor Protein p53
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EGFR protein, human
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ErbB Receptors