CBP80 choreographs the NMD two-step

Pavel Ivanov; Paul Anderson

doi:10.1016/j.molcel.2010.07.035

CBP80 choreographs the NMD two-step

Mol Cell. 2010 Aug 13;39(3):317-8. doi: 10.1016/j.molcel.2010.07.035.

Authors

Pavel Ivanov¹, Paul Anderson

Affiliation

¹ Department of Medicine, Harvard Medical School, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA. [email protected]

PMID: 20705234
DOI: 10.1016/j.molcel.2010.07.035

Abstract

In this issue of Molecular Cell, Hwang et al. (2010) show that the cap-binding protein CBP80 promotes nonsense-mediated decay (NMD) at two steps. In this dual capacity, CBP80 may facilitate essential communication between the premature termination codon (PTC) and the exon-junction complex (EJC) to trigger NMD.

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