Amide-Directed Arylation of sp C-H Bonds using Pd(II) and Pd(0) Catalysts

Masayuki Wasa; Jin-Quan Yu

doi:10.1016/j.tet.2010.03.111

Amide-Directed Arylation of sp C-H Bonds using Pd(II) and Pd(0) Catalysts

Tetrahedron. 2010 Jun 26;66(26):4811-4815. doi: 10.1016/j.tet.2010.03.111.

Authors

Masayuki Wasa¹, Jin-Quan Yu

Affiliation

¹ Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Abstract

Protocols to effect β-arylation of sp(3) C-H bonds via Pd(II)/(IV) and Pd(0)/(II) catalytic cycles have been achieved using a newly developed monodentate CONHC(6)F(5) directing group. These reactions provide an unprecedented means to functionalize sp(3) C-H bonds in aliphatic carboxylic acid-derived substrates.

Abstract

Grants and funding