Abstract
TMPHPG (N,N'-trimethylenebis[2-(2-hydroxy-3,5-dimethylphenyl)glycine]) is a derivative of the ligand EHPG (ethylenebis[2-(o-hydroxyphenyl)glycine]) but is more lipophilic and had been synthesized to increase hepatobiliary clearance. 59Fe(III), 68Ga(III) and 111In(III) complexes of this ligand have been investigated as potential imaging agents for MRI, PET and SPECT, respectively. Metal-dependent differences in blood and liver clearance in mature rats have been evaluated.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Bile / metabolism
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Chemical Phenomena
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Chemistry, Physical
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Chromatography, Thin Layer
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Ethylenediamines* / chemistry
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Female
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Gallium / chemistry
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Gallium / pharmacokinetics*
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Gallium Radioisotopes
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Glycine / analogs & derivatives*
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Glycine / chemistry
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Indium / chemistry
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Indium / pharmacokinetics*
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Indium Radioisotopes
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Iron / chemistry
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Iron / pharmacokinetics*
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Iron Radioisotopes
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Liver / metabolism
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Radionuclide Imaging / methods*
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Rats
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Rats, Inbred Strains
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Stereoisomerism
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Tissue Distribution
Substances
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Ethylenediamines
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Gallium Radioisotopes
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Indium Radioisotopes
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Iron Radioisotopes
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Indium
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ethylenediamine-N,N'-bis(2-hydroxyphenylacetic acid)
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N,N'-trimethylenebis(2-(2-hydroxy-3,5-dimethylphenyl)glycine)
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Gallium
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Iron
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Glycine