Synthesis and antiplasmodial activity of highly active reverse analogues of the antimalarial drug candidate fosmidomycin

ChemMedChem. 2010 Oct 4;5(10):1673-6. doi: 10.1002/cmdc.201000276.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldose-Ketose Isomerases / antagonists & inhibitors*
  • Aldose-Ketose Isomerases / genetics
  • Aldose-Ketose Isomerases / metabolism
  • Antimalarials / chemical synthesis*
  • Antimalarials / chemistry
  • Antimalarials / pharmacology
  • Cell Line
  • Escherichia coli / enzymology
  • Fosfomycin / analogs & derivatives*
  • Fosfomycin / chemical synthesis
  • Fosfomycin / chemistry
  • Fosfomycin / pharmacology
  • Humans
  • Hydroxamic Acids / chemistry
  • Multienzyme Complexes / antagonists & inhibitors*
  • Multienzyme Complexes / genetics
  • Multienzyme Complexes / metabolism
  • Oxidoreductases / antagonists & inhibitors*
  • Oxidoreductases / genetics
  • Oxidoreductases / metabolism
  • Plasmodium falciparum / enzymology
  • Recombinant Proteins / antagonists & inhibitors
  • Recombinant Proteins / genetics
  • Recombinant Proteins / metabolism

Substances

  • Antimalarials
  • Hydroxamic Acids
  • Multienzyme Complexes
  • Recombinant Proteins
  • Fosfomycin
  • fosmidomycin
  • Oxidoreductases
  • 1-deoxy-D-xylulose 5-phosphate reductoisomerase
  • Aldose-Ketose Isomerases