Effect of goniothalamin on the development of Ehrlich solid tumor in mice

Débora Barbosa Vendramini-Costa; Ilton Barros Daltro de Castro; Ana Lúcia Tasca Góis Ruiz; Cilene Marquissolo; Ronaldo Aloise Pilli; João Ernesto de Carvalho

doi:10.1016/j.bmc.2010.07.053

Effect of goniothalamin on the development of Ehrlich solid tumor in mice

Bioorg Med Chem. 2010 Sep 15;18(18):6742-7. doi: 10.1016/j.bmc.2010.07.053. Epub 2010 Jul 27.

Authors

Débora Barbosa Vendramini-Costa¹, Ilton Barros Daltro de Castro, Ana Lúcia Tasca Góis Ruiz, Cilene Marquissolo, Ronaldo Aloise Pilli, João Ernesto de Carvalho

Affiliation

¹ Programa de Pós-graduação em Biologia Celular e Estrutural, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), CP 6109, 13083-970 Campinas, SP, Brazil.

PMID: 20729093
DOI: 10.1016/j.bmc.2010.07.053

Abstract

In this work the antiproliferative activity of goniothalamin (1), both in racemic and in its enantiomeric pure forms, in a solid tumor experimental model using laboratory animals is described. The antiedematogenic activity displayed by racemic 1 in the carrageenan edema model in mice together with the reduction of Ehrlich solid tumor model suggest a relationship between anticancer and antiinflammatory activities with the antiinflammatory activity favoring the antiproliferative activity itself.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / therapeutic use*
Anti-Inflammatory Agents / toxicity
Antineoplastic Agents / chemistry
Antineoplastic Agents / therapeutic use*
Antineoplastic Agents / toxicity
Carcinoma, Ehrlich Tumor / drug therapy*
Carrageenan / toxicity
Cell Line, Tumor
Disease Models, Animal
Edema / chemically induced
Edema / drug therapy
Humans
Mice
Pyrones / chemistry
Pyrones / therapeutic use*
Pyrones / toxicity
Stereoisomerism

Substances

Anti-Inflammatory Agents
Antineoplastic Agents
Pyrones
goniothalamin
Carrageenan