Long-chain O-ascarosyl-alkanediols are constitutive components of Caenorhabditis elegans but do not induce dauer larva formation

Vyacheslav Zagoriy; Vitaliy Matyash; Teymuras Kurzchalia

doi:10.1002/cbdv.201000012

Long-chain O-ascarosyl-alkanediols are constitutive components of Caenorhabditis elegans but do not induce dauer larva formation

Chem Biodivers. 2010 Aug;7(8):2016-22. doi: 10.1002/cbdv.201000012.

Authors

Vyacheslav Zagoriy¹, Vitaliy Matyash, Teymuras Kurzchalia

Affiliation

¹ Max-Planck Institute for Cell Biology and Genetics, Pfotenhauerstrasse 108, D-01307 Dresden. [email protected]

PMID: 20730964
DOI: 10.1002/cbdv.201000012

Abstract

Two long-chain ascarosides, O-ascarosylnonacosane-2,28-diol and O-ascarosyluntriacontane-2,30-diol, were isolated from Caenorhabditis elegans and detected in all developmental stages of the worm. The long-chain ascarosides were shown to be minor lipid components, and it was also shown that they do not induce dauer larva formation.

MeSH terms

Animals
Caenorhabditis elegans / chemistry*
Caenorhabditis elegans / drug effects
Caenorhabditis elegans / growth & development
Chromatography, Thin Layer
Glycolipids / chemistry*
Glycolipids / isolation & purification
Glycolipids / pharmacology
Larva / drug effects
Models, Chemical

Substances

Glycolipids
O-ascarosylnonacosane-2,28-diol
O-ascarosyluntriacontane-2,30-diol