Abstract
In this issue, a study by Groehler and Lannigan (2010. J. Cell Biol. doi:10.1083/jcb.201002124) sheds light on the regulation of proliferating cell nuclear antigen (PCNA) turnover and how it is counteracted by the small chromatin-bound kinase ERK8 (extracellular signal-regulated kinase 8). Importantly, inactivation of ERK8 results in genome instability and is associated with cell transformation.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Cell Transformation, Neoplastic
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Chromatin / metabolism
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DNA Damage
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Extracellular Signal-Regulated MAP Kinases / metabolism*
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Genomic Instability
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Humans
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Proliferating Cell Nuclear Antigen / metabolism*
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Protein Binding
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Proto-Oncogene Proteins c-mdm2 / metabolism*
Substances
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Chromatin
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Proliferating Cell Nuclear Antigen
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MDM2 protein, human
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Proto-Oncogene Proteins c-mdm2
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Extracellular Signal-Regulated MAP Kinases
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MAPK15 protein, human