Ovarian serous cystadenofibroma with signet ring-stromal cells: report of 2 cases

Int J Gynecol Pathol. 2010 Sep;29(5):411-4. doi: 10.1097/PGP.0b013e3181d2973d.

Abstract

We report 2 ovarian serous cystadenofibromas with signet ring cells within the stromal component. The signet ring-stromal cells were widespread in 1 case and focal in the other. Immunohistochemically, they were negative with cytokeratin and other epithelial markers and positive with mesenchymal markers. The occurrence of signet ring-stromal cells in ovarian serous cystadenofibromas is an unusual pseudoneoplastic phenomenon, which has not been reported previously, although signet ring cells may occur within a variety of ovarian stromal neoplasms, including fibromas, sclerosing stromal tumors, and signet ring-stromal tumors. In reporting these cases, we review ovarian stromal neoplasms and other lesions with signet ring cells.

Publication types

  • Case Reports

MeSH terms

  • Adenofibroma / metabolism
  • Adenofibroma / pathology*
  • Aged
  • Biomarkers, Tumor / analysis
  • Female
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Ovarian Neoplasms / metabolism
  • Ovarian Neoplasms / pathology*
  • Stromal Cells / metabolism
  • Stromal Cells / pathology*

Substances

  • Biomarkers, Tumor