Abstract
The dual native chemical ligation at lysine strategy was revised by replacing the acid-labile Cbz protecting group with photolabile NVOC at the 4-mercaptolysine side chain. The optimized strategy was subsequently applied to the synthesis of K48-linked diubiquitin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzaldehydes / chemical synthesis
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Benzaldehydes / chemistry
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Lysine / chemical synthesis
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Lysine / chemistry*
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Ubiquitins / chemical synthesis*
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Ubiquitins / chemistry
Substances
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Benzaldehydes
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NVOC-chloride
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Ubiquitins
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Lysine