The authors analyze the recent treatment regimens of malaria, related to Plasmodium strains and clinical manifestation. Chloroquine is the first choice drug for uncomplicated chloroquine-sensitive P. falciparum, whereas for P. malariae, P. vivax and P. ovale infections treatment with chloroquine plus primaquine is also recommended. For uncomplicated chloroquine-resistant P. falciparum infections many treatment regimens are available. Management of complications is also analyzed.