Application of volume-selected, two-dimensional multiple-quantum editing in vivo to observe cerebral metabolites

Magn Reson Med. 1990 Dec;16(3):496-502. doi: 10.1002/mrm.1910160317.

Abstract

The volume selection technique SPACE has been combined with a two-dimensional multiple-quantum editing sequence to uniquely detect certain J-coupled cerebral metabolites. In vivo results demonstrating edited glutamate/glutamine and lactate from 0.4 ml of a rat's brain at 4.7 T are presented. The sequence was optimized to balance multiple-quantum generation and signal loss due to T2 relaxation. Without due regard to T2 relaxation little signal is observed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / anatomy & histology*
  • Magnetic Resonance Spectroscopy* / methods
  • Rats