Abstract
CD4(178)-PE40 is a recombinant protein consisting of the HIV envelope glycoprotein-binding region of human CD4 linked to active domains of Pseudomonas aeruginosa exotoxin A. The hybrid toxin selectively kills HIV-infected human T-cell lines and protects against HIV spread in mixtures of uninfected and infected cells. We now report that CD4(178)-PE40 also selectively kills chronically HIV-1-infected cells of monocyte/macrophage lineage. The results provide further support for therapeutic use of this hybrid toxin in the treatment of HIV-infected individuals.
MeSH terms
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ADP Ribose Transferases*
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Acquired Immunodeficiency Syndrome / drug therapy
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Antiviral Agents / pharmacology*
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Bacterial Toxins / pharmacology*
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CD4 Antigens*
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Cell Line
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Exotoxins / pharmacology*
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HIV-1 / drug effects
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Humans
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Immunotoxins / pharmacology*
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Leukocytes / drug effects*
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Leukocytes / microbiology
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Lymphocytes / drug effects
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Lymphocytes / microbiology
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Macrophages / drug effects*
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Macrophages / microbiology
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Monocytes / drug effects
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Monocytes / microbiology
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Pseudomonas aeruginosa Exotoxin A
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Recombinant Proteins / pharmacology*
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Virulence Factors*
Substances
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Antiviral Agents
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Bacterial Toxins
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CD4 Antigens
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CD4-Pseudomonas toxin
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Exotoxins
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Immunotoxins
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Recombinant Proteins
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Virulence Factors
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ADP Ribose Transferases