Tandem vinylogous 1,2-addition/anionic oxy-Cope reaction leading from butadiene sulfone to an orthogonally functionalized bicycle

J Org Chem. 2010 Sep 17;75(18):6312-5. doi: 10.1021/jo101389c.

Abstract

Here we present a transition metal-free synthesis of a rigid, orthogonally functionalized bicyclic sulfone, starting from readily available reagents. The transformation proceeds via a tandem vinylogous 1,2-addition/anionic oxy-Cope sequence, followed by a second vinylogous ketone addition. Stereochemical assignments suggest that the anionic oxy-Cope reaction proceeds exclusively through a boat-shaped transition state. The product of the two-step sequence can be further functionalized through subsequent chemo- and diastereoselective transformations, suggesting possible applications in medicinal chemistry or materials chemistry.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anions / chemistry
  • Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis*
  • Bridged Bicyclo Compounds, Heterocyclic / chemistry
  • Butadienes / chemistry*
  • Crystallography, X-Ray
  • Cyclization
  • Models, Molecular
  • Molecular Structure
  • Stereoisomerism
  • Sulfones / chemical synthesis*
  • Sulfones / chemistry*

Substances

  • Anions
  • Bridged Bicyclo Compounds, Heterocyclic
  • Butadienes
  • Sulfones