Abstract
Eucapsitrione (1), an anthraquinone derivative with an indeno-anthracene-trione skeleton, was isolated from the cyanobacterium Eucapsis sp. (UTEX 1519) by bioassay-guided fractionation. The chemical structure was determined by analyzing MS and 1D and 2D NMR spectroscopic data. Eucapsitrione (1) showed anti-Mycobacterium tuberculosis activity in the microplate Alamar blue assay and low-oxygen-recovery assay with MIC values of 3.1 and 6.4 microM, respectively.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthraquinones / chemistry
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Anthraquinones / isolation & purification*
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Anthraquinones / pharmacology*
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Antitubercular Agents / chemistry
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Antitubercular Agents / isolation & purification*
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Antitubercular Agents / pharmacology*
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Candida albicans / drug effects
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Chlorocebus aethiops
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Cyanobacteria / chemistry*
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Escherichia coli / drug effects
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Fresh Water
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Microbial Sensitivity Tests
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Molecular Structure
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Mycobacterium smegmatis / drug effects
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Mycobacterium tuberculosis / drug effects*
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Staphylococcus aureus / drug effects
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Vero Cells
Substances
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Anthraquinones
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Antitubercular Agents
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eucapsitrione