Abstract
A palladium-catalyzed addition of arylboronic acids to phthalaldehyde, followed by an intramolecular lactonization to access 3-substituted phthalides, is described. The procedure tolerates a series of functional groups, such as methoxyl, fluoro, chloro, and trifluoromethyl groups. It represents a procedure for the synthesis of 3-substituted phthalides.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzofurans / chemical synthesis*
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Benzofurans / chemistry
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Boronic Acids / chemistry
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Catalysis
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Cyclization
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Lactones / chemistry*
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Molecular Structure
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Palladium / chemistry*
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Stereoisomerism
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o-Phthalaldehyde / chemistry*
Substances
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Benzofurans
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Boronic Acids
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Lactones
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Palladium
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o-Phthalaldehyde
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phthalide