Thermodynamic aspects of solubility process of some sulfonamides

J Pharm Biomed Anal. 2011 Jan 5;54(1):222-4. doi: 10.1016/j.jpba.2010.07.039. Epub 2010 Aug 6.

Abstract

The thermodynamic aspects of solubility process of sulfonamides with the general structures C(6)H(5)-SO(2)NH-C(6)H(4)-R (R=4-NO(2); 4-Cl) and 4-NH(2)-C(6)H(4)-SO(2)NH-C(6)H(4)-R (R=4-NO(2); 4-CN; 4-Cl; 4-OMe; 4-C(2)H(5)) in water, phosphate buffer with pH 7.4 and n-octanol (as phases modeling various drug delivery pathways) were studied using the isothermal saturated method.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 1-Octanol / chemistry*
  • Anti-Infective Agents / analysis*
  • Anti-Infective Agents / chemistry
  • Buffers
  • Chemistry Techniques, Analytical
  • Chemistry, Pharmaceutical / methods
  • Drug Delivery Systems
  • Hydrogen-Ion Concentration
  • Models, Chemical
  • Solubility
  • Solvents / chemistry
  • Sulfonamides / analysis*
  • Sulfonamides / chemistry
  • Temperature
  • Thermodynamics*
  • Water / chemistry

Substances

  • Anti-Infective Agents
  • Buffers
  • Solvents
  • Sulfonamides
  • Water
  • 1-Octanol