Excitation function for deuteron induced nuclear reactions on natural ytterbium for production of high specific activity 177g Lu in no-carrier-added form for metabolic radiotherapy

Simone Manenti; Flavia Groppi; Andrea Gandini; Luigi Gini; Kamel Abbas; Uwe Holzwarth; Federica Simonelli; Mauro Bonardi

doi:10.1016/j.apradiso.2010.08.008

Excitation function for deuteron induced nuclear reactions on natural ytterbium for production of high specific activity 177g Lu in no-carrier-added form for metabolic radiotherapy

Appl Radiat Isot. 2011 Jan;69(1):37-45. doi: 10.1016/j.apradiso.2010.08.008. Epub 2010 Aug 13.

Authors

Simone Manenti¹, Flavia Groppi, Andrea Gandini, Luigi Gini, Kamel Abbas, Uwe Holzwarth, Federica Simonelli, Mauro Bonardi

Affiliation

¹ LASA, Università degli Studi di Milano and INFN-Milano, via F.lli Cervi 201, I-20090 Segrate (MI), Italy. [email protected]

PMID: 20801665
DOI: 10.1016/j.apradiso.2010.08.008

Abstract

Deuteron-induced nuclear reactions for generation of no-carrier-added Lu radionuclides were investigated using the stacked-foil activation technique on natural Yb targets at energies up to E(d)=18.18 MeV. Excitation functions of the reactions (nat)Yb(d,xn)(169,170,171,172,173,174g,174m,176m,177g)Lu and (nat)Yb(d,pxn)(169,175,177)Yb have been measured, among them three ((169)Lu, (174m)Lu and (176m)Lu) are reported for the first time. The upper limit of the contamination from the long-lived metastable level (177m)Lu was evaluated too. Thick-target yields for all investigated radionuclides are calculated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Deuterium / chemistry
Humans
Lutetium / chemistry*
Nuclear Medicine / methods
Radioisotopes / chemistry*
Ytterbium / chemistry*

Substances

Radioisotopes
Lutetium
Deuterium
Ytterbium