A technique in which solid intracranial lesions are removed using computerized image processing under stereotactic conditions is described. A specially developed carbon fiber ring holder compatible with most image studies is used as a reference system. Intraoperatively it affords freedom of patient positioning and unobstructed access to any site of the head. Four position alternatives of the aiming device allow the removal of lesions from any location. For superficial lesions located near eloquent areas, a 'centered' craniotomy is performed, usually under local anesthesia, and removal is performed using loupe magnification, bipolar coagulation ultrasonic aspiration of the Nd:YAG laser fiber in the contact or noncontact technique. In deep-seated lesions, a surgical 'corridor' is established and kept by means of retractors adapted for use with the stereotactic apparatus. Microsurgical techniques and the CO2 laser are used in solid lesions; in vascular lesions, bipolar coagulation or the ND:YAG laser can be used. Centered craniotomy allows the precise localization, enhancement, three-dimensional orientation and removal of lesions with minimal trauma to the surrounding brain. The technique has been applied in 78 cases where the extreme accuracy of the technique, benign postoperative course and short hospitalization have been impressive.