Stereotactic acquisition of neuroradiological data, followed by identification of cerebral structures and three-dimensional rendering, has been successfully applied to guided microsurgical resection of deep-seated cerebral lesions. The method described utilizes data from magnetic resonance, computed tomography, and digital angiography and allows the surgeon to 'wire frame' the lesion volume and the position of cerebral vessels and structures of high functional relevance. Three-dimensional rendering of surgical instrumentation around the reconstructed anatomy allows for planning and simulation of the trajectory of approach.