Although medical treatment of atherosclerotic processes as a cause of the coronary artery disease has its own fundamental role, percutaneous coronary interventions showed an impressing development due to the intensive innovation. The use of stents increased the success rate of percutaneous coronary interventions, but in-stent restenosis appeared as a new complication. Drug eluting stents are dedicated to decrease the frequency of intima proliferation facilitating in-stent restenosis. After implantation of a drug-eluting stent, in-stent restenosis occurs in less than 10% of the patients. In spite of the improving results, in-stent restenosis of a drug-eluting stent has been remained unsolved. Besides the biodegradable stents/polymers, drug-eluting balloon may indicate the future technology. In this paper a very exciting, educative case is presented with a summary of the literature of drug-eluting balloon technique.