Insights into the targeted elimination of BRCA1-defective cancer stem cells

Veena Somasundaram; Priya Srinivas

doi:10.1002/med.20229

Insights into the targeted elimination of BRCA1-defective cancer stem cells

Med Res Rev. 2012 Sep;32(5):948-67. doi: 10.1002/med.20229. Epub 2010 Sep 2.

Authors

Veena Somasundaram¹, Priya Srinivas

Affiliation

¹ Integrated Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thycaud PO, Thiruvananthapuram 695 014, Kerala, India.

PMID: 20814958
DOI: 10.1002/med.20229

Abstract

BRCA1 expression is involved in normal embryonic development, mammary stem cell differentiation, and prostate cancer development. Inactivation of BRCA1 plays an important role in cancer stem cells and also leads to the development of high-grade, basal-like tumor. This review discusses why BRCA1-defective cancer stem cells need a prospective analysis, how ER alpha could influence BRCA1-defective tumor progression, phenotype of BRCA1-defective cancers, role of BRCA1 in other cancers and finally at what perspective BRCA1-defective cancers can be targeted for better therapeutic outcome.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
BRCA1 Protein / metabolism*
Breast Neoplasms / metabolism*
Breast Neoplasms / pathology*
Disease Models, Animal
Female
Humans
Neoplastic Stem Cells / metabolism*
Neoplastic Stem Cells / pathology*
Poly(ADP-ribose) Polymerase Inhibitors
Poly(ADP-ribose) Polymerases / metabolism
Receptors, Estrogen / metabolism

Substances

BRCA1 Protein
Poly(ADP-ribose) Polymerase Inhibitors
Receptors, Estrogen
Poly(ADP-ribose) Polymerases