Methylerythritol cyclodiphosphate (MEcPP) in deoxyxylulose phosphate pathway: synthesis from an epoxide and mechanisms

Chem Commun (Camb). 2010 Oct 14;46(38):7220-2. doi: 10.1039/c0cc02594a. Epub 2010 Sep 1.

Abstract

In this communication, we reported another unique IspG-catalyzed transformation, the production of its substrate, MEcPP, from (2R,3R)-4-hydroxy-3-methyl-2,3-epoxybutanyl diphosphate (Epoxy-HMBPP) when reductants are excluded from the reaction mixture.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alkyl and Aryl Transferases / metabolism*
  • Bacteria / enzymology*
  • Chlorophyta / enzymology*
  • Epoxy Compounds / metabolism*
  • Erythritol / analogs & derivatives
  • Organophosphates / metabolism*
  • Plants / enzymology*
  • Signal Transduction
  • Xylose / analogs & derivatives*
  • Xylose / metabolism

Substances

  • 4-hydroxy-3-methyl-2-butenyl diphosphate
  • Epoxy Compounds
  • Organophosphates
  • deoxyxylulose phosphate
  • methyl-D-erythritol 2,4-cyclodiphosphate
  • Xylose
  • Alkyl and Aryl Transferases
  • Erythritol