Abstract
A new series of thiazole-substituted 1,1,1,3,3,3-hexafluoro-2-propanols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Key analogs caused dose-dependent decreases in food intake and body weight in obese mice. Acute treatment with these compounds also led to a drop in elevated blood glucose in a murine model of type II diabetes.
Published by Elsevier Ltd.
MeSH terms
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Animals
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Anti-Obesity Agents / chemical synthesis
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Anti-Obesity Agents / chemistry
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Anti-Obesity Agents / pharmacology
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Anti-Obesity Agents / therapeutic use*
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Blood Glucose / drug effects
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Body Weight / drug effects
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Carboxy-Lyases / antagonists & inhibitors*
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Carboxy-Lyases / metabolism
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Diabetes Mellitus, Type 2 / drug therapy*
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Drug Design*
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Eating / drug effects
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Humans
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Hypoglycemic Agents / chemical synthesis
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Hypoglycemic Agents / chemistry
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Hypoglycemic Agents / pharmacology
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Hypoglycemic Agents / therapeutic use*
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Mice
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Mice, Inbred C57BL
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Obesity / drug therapy*
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Propanols / chemical synthesis
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Propanols / chemistry
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Propanols / pharmacology
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Propanols / therapeutic use*
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Thiazoles / chemical synthesis
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Thiazoles / chemistry
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Thiazoles / pharmacology
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Thiazoles / therapeutic use
Substances
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Anti-Obesity Agents
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Blood Glucose
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Hypoglycemic Agents
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Propanols
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Thiazoles
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hexafluoroisopropanol
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Carboxy-Lyases
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malonyl-CoA decarboxylase